SAFETY TESTS

The following safety tests were performed on the raw material '' Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40 ''.

   - Cell toxicity (in-House Lab.)
   - Bacterial Reverse Mutation Assay test (GLP Lab.)
   - Chromosomal test (GLP Lab.)

The following additional tests are conducted on the safety of 'Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40' and animal testing of this ingredient is never carried out.

   - Skin Irritation using EPISKIN
   - Eye Irritation using EpiOcular test​
   - Skin Sensitization : Local Lymph node Assay : BrdU-ELISA)​
   - in vitro 3T3 NRU Photoxity Test 

CLINICAL TESTS

Single Human Patch Test 
Bolca Anti-Wrinkle Facial Serum
(I.E.C. Korea @ Chonnam National Univ. Hospital)

Clinical Test (I.E.C. Korea)
Bolca Anti-Wrinkle Facial Serum
(I.E.C. Korea)

D0

D28

Roughness

Net Elasticity

Nasolabial line

16/22

22/22

15/22

72 %

100 %

68 %

Ratio

Effectivenss

After 4 weeks test shows improvement of roughness, elasticity, nasolabial line from 70% of applicant.  Different from individuals but the efficacy can be seen normally within 2 weeks

BPMed Cosmetic.(Head Office)

4F, 8, Bongeunsa-ro 84-gil, Gangnam-gu, Seoul, Republic of Korea (06163)

Tel: +82-1577-0622 / Fax: +82-2-565-0622  

E-mail: bpmedcosmetic@bpmedcosmetic.com

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