OUR INGREDIENT

Structure of 'Methionyl r-Clostridium Botulinum

Polypeptide-1 Hexapeptide-40'

'Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40' is developed as recombination of peptide called “MTD” (Macro-molecule Transmission Domain) that has function of skin and target cell permeation and, active protein of botulinum toxin called 'Light Chain'.  'MTD' applied to our ingredient is originated and developed from botulinum toxin 'Heavy Chain', ,which performing a cell-penatration function of botulinum toxin. 

Toxin Complex

(Medical Botox Injection)

Botulinum Light Chain A

Botulinum Heavy Chain

Hemaggultinin

Non-toxin

Non-toxin Non-Hemagglutinin

Composition

Heavy chain : Nerve cell penetration

Light chain : Botulinum Efficacy Part

Hemagglutinin

Non-toxin Non-Hemagglutinin

Commercialization

1980

Example

BOTOX (Allergan, US)

MEDITOXIN (Meditox, Korea)

Not permitted to use in Cosmetic Product

Molcular weight

900KDa

Comparison if Botulinum Ingredients

Pure Toxin

(Medical Botox Injection)

Botulinum Light Chain A

Botulinum Heavy Chain

Heavy chain : Nerve cell penetration

Light chain : Botulinum Efficacy Part

1995

XEOMIN (Merz, Germany)

Not permitted to use in Cosmetic Product

150KDa

Our Ingredient

(BPMed_BoLCA_Protein)

Botulinum Light Chain A

MTD Protein

Light Chain + MTD

Botulinum Efficacy Part

Marco-molecule Transmission Domain

(Skin & Nerve cell penetration)

= Recombination of the Protein

2014

BoLCA+ (BPMed cosmetic, Korea)

 

The First Botulinum Ingredient on ICID

BPMed Cosmetic has Exclusivity

50KDa

Skin and Cell Penetration Technology of MTD

Platform technology to improve transdermal delivery of 

'Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40'

1st Action

2nd Action

Improved penetration of functional materials into stratum corneum and other skin layers by MTD.

Maximized efficacy through the delivery of 'Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40' into specific targets.

Epidermis

Dermis

Subcutaneous Tissue

Muscle Layer

Cell

BPMed Cosmetic.(Head Office)

4F, 8, Bongeunsa-ro 84-gil, Gangnam-gu, Seoul, Republic of Korea (06163)

Tel: +82-1577-0622 / Fax: +82-2-565-0622  

E-mail: bpmedcosmetic@bpmedcosmetic.com

© 2020 by BPMed Cosmetic Co., Ltd.